A new paper reviews the neurorestorative strategies for cerebral palsy (CP), a group of permanent nonprogressive disorders caused by damage to the immature brain. It focuses on drugs and cell therapy that have shown beneficial effects in clinical studies.

Neurorestorative drugs: The article discusses various drugs that can improve the functional recovery of neural cells, such as oxiracetam, cerebrolysin, gangliosides, darbepoetin, and erythropoietin. These drugs have anti-inflammatory, anti-apoptotic, neurotrophic, and neuroprotective properties.

Cell therapy: The paper describes different types of cells that can be used for cell therapy in CP, such as bone marrow stem cells, umbilical cord stem cells, neural stem cells, and olfactory ensheathing cells. These cells can repair the brain damage by regeneration, replacement, paracrine activity, and immunomodulation.

Limitations and future directions: The article acknowledges the need for more evidence and guidelines for neurorestorative strategies in CP. It suggests that combining various neuroprotection strategies with cell therapy may enhance the clinical recovery. It also recommends using functional neuroimaging or biomarkers to monitor the effects of neurorestoration.